Hesperidin-Sources, chemistry, extraction, measurement and biologic effects on reproduction in animals: A review

This paper reviewed the polyphenolic compound, hesperidin, found mostly in citrus fruit peels and examined its use animal reproduction. Hesperidin, as a bioflavonoid flavanone glycoside, has wide range of biological therapeutic benefits. Its application enhancement reproductive indices animals is limited due to low water solubility, poor absorption bioavailability. Synthetic variants hesperidin such alpha-glycosyl-hesperidin, hesperidin-7, 3'-O-dimethylether (HDME) methyl chalcone have been developed enhance solubility vis-a-vis In body, it metabolism into hesperitin, which responsible for most actions. The benefits include: antioxidant properties through scavenging free radicals; anti-inflammatory actions, analgesic, metal-chelating antitoxic properties, cardioprotective neuroprotective effects, antibacterial, prevention bone resorption glucose homeostasis. Also, modulates cellular intracellular molecules signaling. effects extraction, metabolites toxicology are discussed review. It was concluded that potent can be used ameliorate oxidative stress exposed severe environmental conditions